RNA-editing is dysregulated in the brains of individuals with autism

Researchers at the University of California, Los Angeles, found that RNA-editing is dysregulated in the brains of individuals with autism spectrum disorder (ASD)1. RNA-editing is a mechanism that occurs inside the cells, whereby the cell’s RNA sequence can be altered, thus changing the information used to build proteins. This process is known to play a […]

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Oxytocin in the autism brain

It is well known that individuals with autism spectrum disorder (ASD) have difficulties in social interactions. However, the biological causes of these difficulties are not well understood. In the brain, many social and associated behaviors are modulated by the release of a chemical compound called oxytocin1. Researchers have hypothesized that social deficits in ASD may […]

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Autism BrainNet begins distribution of new postmortem brain tissue

The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce that Autism BrainNet is beginning to distribute new frozen and fixed postmortem brain tissue from individuals with autism spectrum disorder (ASD) and related neurodevelopmental disorders, as well as neurotypical individuals. To date, the Autism BrainNet collection has received 146 brain donations. This includes 55 […]

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Autism BrainNet Winter 2018 Update

We are happy to share the Winter 2018 issue of the Autism BrainNet newsletter with you. The Autism BrainNet newsletter frequently summarizes the new science and outreach of this program. Read more here.

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The immune system in autism: What does microglia have to do with it?

While much of the research on postmortem autistic brains involves the principal information processing cell, the neuron, there are other cells in the brain that have a variety of functions. Astrocytes and microglia are two types of “glial” cells specific to the central nervous system. While astrocytes have multiple functions, such as contributing to the […]

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Letter from the Director-December 2018

Another year is nearly over. Autism BrainNet continues to expand its activities of collecting critical brain tissue to fuel essential research about autism spectrum disorder. I want to thank the 31 families that made donations to Autism BrainNet in 2018. They have made a precious gift to individuals and families all over the world who […]

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Autism BrainNet Fall 2018 Update

We are happy to share the Fall 2018 issue of the Autism BrainNet newsletter with you. The Autism BrainNet newsletter frequently summarizes the new science and outreach of this program. Read more here.

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Some Shared Characteristics of Fragile X and Autism

Fragile X syndrome (FXS), caused by lack of fragile X mental retardation protein (FMRP), is associated with a high prevalence of autism. In people with duplication of a portion of chromosome 15 (Dup15q), about 80% also have a diagnosis of autism, presumably due to the genetic differences on chromosome 15. It is not clear whether […]

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