Panel on postmortem brain studies highlights new findings on the autism brain

The 2019 International Society for Autism Research (INSAR) meeting was held in Montreal, Canada, May 1-4. This annual event hosted a variety of presentations on the latest autism research, including a panel on ‘Postmortem studies: Functional genomic profiling studies of ASD brain.” Chaired by Daniel Geschwind (University of California, Los Angeles, UCLA), the panel highlighted […]

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Single-cell study identifies brain cell types linked to autism

Research using postmortem brain tissue has helped to identify changes in gene expression and dysregulated pathways associated with autism spectrum disorder (ASD). Because these studies used a ‘bulk’ approach that averages RNA measures across the brain tissue, it has been difficult to assess differences in gene expression specific to the many different cell types in […]

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Autism BrainNet Establishes Collaboration with Douglas-Bell Canada Brain Bank to Promote Research on Autism Spectrum Disorder

Autism BrainNet, a program funded by the New York-based Simons Foundation Autism Research Initiative (SFARI), announces a new collaboration with the Douglas-Bell Canada Brain Bank (DBCBB). This alliance will allow Canadian individuals and families the opportunity to consider making a postmortem brain donation to help advance research on the causes and treatments of autism spectrum […]

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Autism BrainNet Spring 2019 Update

We are happy to share the Spring 2019 issue of the Autism BrainNet newsletter with you. The Autism BrainNet newsletter frequently summarizes the new science and outreach of this program. Read more here.

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Letter from the Director-April 2019

Autism BrainNet Begins New Tissue Distribution – Autism BrainNet was established in 2014 with the goal of collecting postmortem brain tissue to promote research on the causes and potential treatments of autism spectrum (ASD) and other related neurodevelopmental disorders. To date, Autism BrainNet has received 153 brain donations, including 59 from individuals with a confirmed […]

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RNA-editing is dysregulated in the brains of individuals with autism

Researchers at the University of California, Los Angeles, found that RNA-editing is dysregulated in the brains of individuals with autism spectrum disorder (ASD)1. RNA-editing is a mechanism that occurs inside the cells, whereby the cell’s RNA sequence can be altered, thus changing the information used to build proteins. This process is known to play a […]

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Oxytocin in the autism brain

It is well known that individuals with autism spectrum disorder (ASD) have difficulties in social interactions. However, the biological causes of these difficulties are not well understood. In the brain, many social and associated behaviors are modulated by the release of a chemical compound called oxytocin1. Researchers have hypothesized that social deficits in ASD may […]

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Autism BrainNet begins distribution of new postmortem brain tissue

The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce that Autism BrainNet is beginning to distribute new frozen and fixed postmortem brain tissue from individuals with autism spectrum disorder (ASD) and related neurodevelopmental disorders, as well as neurotypical individuals. To date, the Autism BrainNet collection has received 146 brain donations. This includes 55 […]

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